Could it be because you are possibly using amd video driver 15.4 Beta>? If so what GPU are you using it with my friend has a 6950 2GB that is giving her the same issue. Or possibly the same issue it seems to be random have not found a specific map, but she can not load some maps. she completely uninstalled and reinstalled the game. Fixed the issue for a little while only to not load this map desolate sands today. I can only assume this is likely a beta driver issue and as far as i know there is no new driver available yet.

For what? It's been a known problem for about a year now since RoS's release, which pains users with AMD switchable graphics. There are two threads about this on page one alone. The only thing that works is rolling back to AMD drivers from 2013 (13.12 does work, provided you don't use Win 8.1, in which case you could've simply thrown your money in the trash instead of buying D3). The only response from you guys is 'please post your DXdiag' or 'roll back to 13.12', which is plain laughable, especially since I played trough the vanilla game without any problems on the same hardware. Even if it's something in the AMD drivers not working properly, you should be able to get in contact with the AMD guys and figure out what the problem is, but nobody seems to care.

Search for "desolate sands crash AMD" in these forums, there are plenty of threads:
http://us.battle.net/d3/en/search?q=desolate+sands+crash+AMD&f=post&forum=5386227

EU forums:
http://eu.battle.net/d3/en/search?q=desolate+sands+crash+AMD&f=post&forum=4436696

German forums:
http://eu.battle.net/d3/de/search?q=die+trostlosen+sande&f=post&forum=4437172

.. and I'm sure, there's a couple of pages about this problem in every language region.

So why even bother going through the hassle of generating a dxdiag file if the only thing you guys do is either suggest going through the standard "if your computer does something funny"-procedures like reinstalling drivers, etc. or rolling back to a driver that is 2 years old.

I used 13.12 for a while now, but now I got other games complaining about outdated drivers, so I had to decide and since your tech guys obviously can't be arsed to look into this problem, I won't play D3 anymore. I've been buying and playing Blizzard games since Blackhawk for the SNES, every single one. I played WoW for 4 years straight and you guys made hundreds of dollars over the years from my purchases alone. This Bug exists for about a year now and makes the game unplayable for many people, yet the only fix is to use graphics drivers that are so old, it's hard to even find a download. The name 'Blizzard' once stood for a company that cared about their customers, but clearly this has changed over the last couple of years since you fused with Activision and the focus now seems to be solely on the money side of things. As sad as it makes me to say this, but Diablo 3 will be the last game Blizzard sold me. I don't mean to be whining here, I've never complained about any decisions made for your games. But to be let down like this is heartbreaking. Clearly making a quick buck with Heroes of the Storm Heroes and Booster Decks in Hearthstone is now more valuable to Blizzard than the continued support from people for 20 years.